![]() ![]() "Pharmacokinetics and Pharmacodynamics of Inhaled Corticosteroids". ^ Steinhilber, D Schubert-Zsilavecz, M Roth, HJ (2005).^ Christian Hubschwerlen Jean-luc Specklin J."Configurational Assignment of Polyene Macrolide Antibiotics Using the Acetonide Analysis". "3.2.2: Diol Protecting Groups-Acetals-Isopropylidene Acetals". The acetonides of corticosteroid are used in dermatology, because their increased lipophilicity leads to better penetration into the skin. It is a common protecting group for sugars and sugar alcohols, a simple example being solketal. The hexaol mannitol reacts with 2,2-dimethoxypropane to give the bis-acetonide, which oxidizes to give the acetonide of glyceraldehyde: (CHOHCHOHCH 2OH) 2 + 2 (MeO) 2CMe 2 → (CHOHCHCH 2O 2CMe 2) 2 + 4 MeOH (CHOHCHOCH 2OCMe 2) 2 + → 2 OCHCHCH 2O 2CMe 2 + H 2OĪn example of its use as a protecting group in a complex organic synthesis is the Nicolaou Taxol total synthesis. The acetonides of small di- and triols, as well as many sugars and sugar alcohols, are common. The protecting group can be removed by hydrolysis of the ketal using dilute aqueous acid. ![]() Acetonide is a common protecting group for 1,2- and 1,3- diols. Having up-to-date drivers is essential for maximum PC performance.Driver-Reviver uses industry-leading technology with the largest driver database to quickly identify out-of-date drivers and easily updates them with a few mouse clicks.With Driver-Reviver, all your peripherals will work, and you will experience a faster and optimized PC. The more systematic name for this structure is an isopropylidene ketal. In organic chemistry, an acetonide is the functional group composed of the cyclic ketal of a diol with acetone. The diol is shown in blue, the acetone part in red. ![]()
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